Evaluation of renal ischemia-reperfusion injury by magnetic resonance imaging texture analysis: An experimental study.

Abstract

To explore the value of MRI texture analysis in evaluating the presence and severity of early renal ischemia-reperfusion injury (IRI). Healthy New Zealand rabbits were used (IRI group, N=54; control group, N=8). Rabbits in the IRI group underwent left renal artery clamping for 60minutes. Magnetic resonance imaging was performed before and at 1, 12, 24, and 48hours after IRI. The relationship between MRI texture features and histopathology parameters was assessed using Pearson's correlation coefficients. The diagnostic performance of texture features in kidney differentiation at different time points was assessed by receiver operating characteristic curve analysis. T2 WI_S(3,-3)Inverse_Difference_Moment had the strongest correlation with brush border destruction, tubular epithelial edema, necrosis, and cast (r=0.56, -0.58, 0.62, and 0.69, respectively; all P<.001). BOLD_S(4,-4)Correlation had the strongest correlation with interstitial inflammatory cell infiltration (r=0.63, P<.001). SWI_S(4,4)Difference_Entropy had the strongest correlation with microvessel density (r=0.61, P<.001). The areas under the curve for T2 WI_S(3,-3)Inverse_Difference_Moment, SWI_S(4,4)Difference_Entropy, and BOLD_S(4,-4)Correlation in kidney differentiation before IRI and that at 1 and 12hours after reperfusion were 0.76, 0.72, and 0.70, respectively; the values before IRI and at 24 and 48hours after reperfusion were 0.84, 0.81, and 0.69, respectively. The area under the curve for T2 WI_S(3,-3)Inverse_Difference_Moment in kidney differentiation at 1 and 12hours after reperfusion and that at 24 and 48hours after reperfusion was 0.66. Magnetic resonance imaging texture analysis can be used for evaluating the presence and severity of early renal IRI.