Evaluation of remineralizing potential of Calcium Sucrose Phosphate and CPP-ACP: An in vitro study

Abstract

BackgroundIn depth understanding of dental caries progression and improved diagnostic methodologies to assess early demineralization has enabled development of novel remineralizing therapeutics. Hence, an emerging goal of modern dentistry is to manage non-cavitated carious lesions non-invasively through remineralization. ObjectiveTo evaluate the remineralizing potential of Calcium Sucrose Phosphate (CaSP) and Caesine PhosphoPeptide-Amorphous Calcium Phosphate (CPP-ACP) on early enamel lesions. MethodThirty enamel specimens were prepared from freshly extracted noncarious molars and artificial enamel subsurface lesions were induced. The sample was randomly divided into 3 groups based on the surface treatment i.e. Group A – Control (no surface treatment) Group B – CPP-ACP cream, Group C – CaSP paste. A caries progression test (pH cycling) was carried out for 12 days. All enamel specimens were subjected to quantitative and qualitative analyses at baseline, after demineralization and after remineralisation using Vickers microhardness test and Scanning Electron Microscopy respectively. ResultsStatistical analysis using one-way ANOVA followed by multiple comparisons test was applied to detect significant differences at P ≤ 0.05 levels. The mean surface microhardness recovery with CaSP was significantly higher than other groups. ConclusionThe CaSP paste was effective in remineralizing early enamel lesions than CPP-ACP.