Evaluation of relationship between myocardial injury and left ventricular mechanical dyssynchrony using 99Tcm-MIBI myocardial perfusion SPECT and 18F-FDG myocardial metabolic PET imaging

Abstract

Objective To investigate the relationship between myocardial injury and damage of mechanical synchrony in the left ventricle of patients with ischemic cardiomyopathy (ICM) using 99Tcm-MIBI MPI and gated 18F-FDG myocardial metabolic PET imaging. Methods A total of 113 ICM patients (100 males, 13 females; average age (58±10) years) underwent 99Tcm-MIBI MPI and gated 18F-FDG myocardial metabolic PET imaging from July 2015 to December 2015 in Fu Wai Hospital were retrospectively analyzed. Three-point scoring system was used for quantitative assessment of myocardial ischemia and myocardial infarction in each segment. Total ischemic score (TIS) and total scar score (TSS) of 17 segments were calculated in each patient. The phase bandwidth (BW) and phase SD were derived from phase analysis. Pearson correlation analysis and logistic regression analysis were used. Results TSS were correlated with BW and SD in all 93 patients with myocardial infarction (r values: 0.517, 0.470, both P 0.05). Logistic regression analysis showed that the number of myocardial infarction segments and TSS were associated with mechanical dyssynchrony. Conclusion Myocardial infarction is the main factor of left ventricular mechanical dyssynchrony in ICM patients, but chronic myocardial ischemia has no significant influence on mechanical dyssynchrony. Key words: Myocardial ischemia; Myocardial contraction; Myocardial perfusion imaging; Tomography, emission-computed, single-photon; Positron-emission tomography; Technetium Tc 99m sestamibi; Deoxyglucose