Evaluation of Red Cell Distribution Width and Neutrophil Lymphocyte Ratio as prognostic factors in Hypertensive Disease of Pregnancy

Abstract

Background: Preeclampsia is characterized by hypertension and proteinuria starting from 20 weeks of gestational age or more with previous normal blood pressure.The most unbreakable theory about preeclampsia pathophysiology is the change of immunological system leading to increased inflammation response. Objective:The aim of this study is to compare RDW and NLR in normal pregnant women and in women with PHD to evaluate whether these parameters have a prognostic significance in diagnosing and determining the severity of PHD. Methods:A case–control retrospective study was carried out on a total of 536 pregnant women who have met the inclusion criteria with 300normotensive women(55.97%)as control and 236women with PHD(44.03%)as cases which subdivided into 3 subgroups:de-novo gestational hypertension(n=100),mild PET(n=50),severe PET and/or eclampsia(n=86). Results:The mean RDW-CV in the control group was 13.83±0.87,where in PHD group was15.91±1.44with a p-value of<0.001.Also,in the subgroup analysis, there was a difference in mean RDW-CV between women with G.HTN(15.47±1.21),mild PET(15.63±1.18)and severe PET(16.47±1.63)with a p-value of Conclusions: RDW, NLR and PDW can be used as simple, applied, non-invasive and inexpensive parameter for prediction and prognosis of PHD.