Abstract
AbstractTumor cells, thymocytes and lymph node cells in normal and tumor‐bearing mice treated with recombinant human tumor necrosis factor (rH‐TNF) were analyzed using automated cell electrophoresis to measure and classify cells according to cell surface charge. In the benzopyrene‐induced tumor system the intratumoral administration of rH‐TNF caused marked tumor necrosis and an increased cell surface charge on the tumor cells as detected by increased electrophoretic mobility (EPM). The thymus and lymph node are involved during murine tumor development characterized by abnormal weight and EPM pattern of lymphocyte histograms. Thymocyte and lymph node histograms were restored to their normal pattern by treatment of tumor bearers with rH‐TNF. The analysis of electrophoretic patterns of murine tumor cells, thymocytes and lymph node cells may be a simple method to evaluate drug effects on the immune system when automated techniques are applied.
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