EVALUATION OF RECEPTOR STATUS IN CARCINOMA BREAST

Abstract

Background/Objective: In Indian population, there has been a fairly steady and large increase in the incidence of breast cancer over the past several decades and its management requires complex multidisciplinary approach to increase overall survival rate. As data for incidence of luminal subtypes is Indian patients is absent which will indicate the prognosis of the patient, this study was taken up to study the incidence of receptor status and hence luminal subtypes in Indian patients. This study was conducted in the Department of Genera Methods: l Surgery at Chigateri General Hospital and Bapuji Hospital attached to J.J.M. Medical college, Davangere. 30 patients with diagnosed carcinoma breast were selected according to the inclusion criteria and tumor tissue was sent to pathology lab to determine the Estrogen Receptor (ER), Progesterone Receptor (PR), Her 2 Neu status and Ki67 index. 50% are above 50 years (post- menopausal) and 90% of the patie Results: nts are females. Histopathological examination showed that 76.6% were diagnosed with IDC and majority of patients are present in stage IIB and stage IIIA . In our study we observed luminal A subtypes comprised of 23.33% of cases where as luminal B subtypes comprised of 20% of cases, Majority of cases i.e. 33.33% were basal like / triple negative with poor prognosis .Her 2 Neu amplied cases comprised 23.33% of total study population which is similar to western population. The receptor status is very different on out study population of Indian patient Conclusion: s as compared to the western population and hence it is recommended that ER, PR, Her 2 Neu and Ki67 index analysis should be performed routinely on all breast cancer patients which changes the treatment plan and impact on the overall survival rate