Abstract
Background: Essential hypertension (EH) has a negative impact on health-related quality of life (H-rQoL) while dyslipedemia very often accompanies the hypertensive sequelae. In this study, we investigated the combined effect of EH and dyslipidemia on H-rQoL. Methods: We studied 145 subjects with newly diagnosed stage I-II untreated EH (aged 56 ± 7 years, 47 = dyslipidemic, office blood pressure = 156/92 mmHg). Venous sampling was performed for estimation of lipidemic profile. The validated Greek version of Short Form 36 (SF-36) General Health Survey questionnaire was administered. The 8 subscales of SF-36 were further grouped into two summary scales: the physical component summary scale (PCS) and the mental component summary scale (MCS). Non-parametric Mann-Whitney and Spearmann rho tests were performed. Results: Dyslipidemic hypertensives demonstrated significantly lower scores in all SF-36 dimensions compared to non dyslipidemic (Table). There was a negative correlation between scores in general health and the total SF-36 score with serum triglycerides level (r = -0.284 p = 0.009, r = -0.287 p = 0.014, respectively). Conclusions: In essential hypertension, dyslipidemia exerts an additive detrimental effect on quality of life. Whether the abovementioned association contributes to the high cardiovascular risk observed in those patients remains to be determined in future studies.
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