Evaluation of Protein, Lipid and Inflammatory Profiles in Patients with Non-Hodgkin Lymphoma in the Western Region of Algeria

Abstract

Introduction: Non-Hodgkin lymphoma (NHL) is part of the lympho-proliferative syndromes, it is a heterogeneous group of tumors whose incidence has been increasing in recent years. A disruption of protein and lipid profiles is verified during this pathology as well as an increase in the levels of specific markers of inflammation.
 Objective: Our study aims to explore protein and lipid profiles and highlight an inflammatory syndrome via the assay of parameters of acute inflammation in patients with NHL and healthy subjects in western Algeria.
 Methods: A case-control study comprising 100 patients with NHL and 40 healthy subjects was carried out. Protein and lipid profiles were respectively studied by assays for total protein and globulins and analysis of cholesterol and triglyceride levels. The inflammatory status was demonstrated by studying two parameters: C reactive protein (CRP) and sedimentation rate (VS).
 Results: Our results demonstrated an increase in alpha1-globulin and a decrease in gamma-globulin in patients compared to controls (p <0.05). The lipid profile study showed no significant difference for cholesterol but a significant increase in triglycerides in patients with NHL (p <0.05). A highly significant difference in CRP and VS levels between our two groups (p <0.01) with a marked increase in patients demonstrated the presence of acute inflammatory syndrome.
 Conclusion: This study allowed us to highlight the alterations in protein and lipid profiles found in NHL and the presence of an inflammatory state, involved in the pathophysiology of non-Hodgkin lymphoma in particular.
 Keywords: non-Hodgkin lymphoma, protein profile, lipid profile, CRP, VS.