Abstract
Abstract This study was to screen strains which had effects on insulin resistance in vitro and explore the possible mechanism. These strains were tested the ability of colonization, hormone release, lipid accumulation, glucose uptake and immunomodulatory. Three strains of Lactobacillus paracasei 1F-20, Lactobacillus fermentum F40-4 and Bifidobacterium animalis subsp. lactis F1-7 led to results as follows: (1) survived in the harsh conditions. (2) increased the hormone release of glucagon-like peptide 1(GLP-1), peptide YY (PYY) and up-regulated genes expression of proglucagon gene (GCG), PYY; (3) decreased lipid accumulation, down-regulated genes expression of sterol regulatory element binding protein-1C (SREBP-1C), patatin-like phospholipase domain containing 3 (PNPLA3) and up-regulated peroxisome proliferator activated receptor-α (PPARα); (4) increased the uptake of glucose and up-regulated the protein expression of phosphatidylinositol 3- kinase (PI3K) and phosphorylated serine-threonine protein kinase (pAKT). (5) decreased the proinflammatory cytokine IL-6 and TNF-α. It demonstrated that the three strains prevented the development of insulin resistance.
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