Evaluation of Prevalence of Changes in Thyroid Functional Tests in Mole Hydatiforme

Abstract

Introduction: Mole hydatiforme is the most common type of gestational trophoblast disease (GTD) and the aim of this study, is evaluation the frequency of changes in thyroid function tests in mole hydatidiform patients. Materials and Methods: In this retrospective study, 63 patients with mole hydatidiform who reffering to gynecology ward of Ali ibn Abitaleb Hospital in Zahedan from April 20 16 to March 20 17, were studied. Information such as age, gravidity and laboratory findings including thyroid function tests (TFT) and the presence or absence of clinical symptoms were recorded in the information forms and analyzed by SPSS software. Results: In this study, 63 patients with mole hydatidiform were studied. The mean age of the patients was 26.6 ± 7.7 years. The most common clinical manifestation of hyperthyroidism in patients with mole hydatiforme was tachycardia (39.7%). There was no relationship between age and gravidity with the hyperthyroid symptoms and thyroid function tests. Conclusion: Overall, the results of this study showed that 67% of patients with mole hydatidiform had reduced TSH and more than 50% of cases had increased free T3 and T4. There was no relationship between maternal age and gravidity with changes in thyroid functional test.