Abstract
Total knee arthroplasty (TKA) is a highly successful operation in the treatment of degenerative knee changes and is in increasing demand worldwide due to the aging population...
Highlights
Total knee arthroplasty (TKA) is a highly successful operation in the treatment of degenerative knee changes and is in increasing demand worldwide due to the aging population and the need to preserve people’s quality of life. It involves extensive tissue trauma, which contributes to the occurrence of severe postoperative pain, and analgesia in this phase is of fundamental importance Zabeu, Migon, Junior [1]
Sampling: Patients who underwent surgical treatment of total knee arthroplast (TKA) within one year from the month of AUGUST 2018, who meet the inclusion criteria mentioned in item 3.4.1, and agree to participate in the research according to Informed Consent (IC), being submitted for evaluation according to the Visual Analog Pain Scale (VAS) and an adverse effects questionnaire
These same neurotransmitters are part of the tramadol antinociception mechanism of action which, through two differents and independents but synergistic mechanisms of action, acts as an opioid agonist and indirectly performs an action contrary to that of pregabalin, as it triggers mechanisms that inhibit the reuptake of noradrenaline and serotonin Driessen [26], Dayer [27]. As this pharmacokinetics of pregabalin and tramadol have been studied in animals and in vitro separately, further studies are needed to elucidate such drug interaction. This is the possible explanation for the fact that in our study similar effects of pain reduction were found between the groups receiving Placebo preoperatively and the pregabalin groups, both 1h before and 24h before surgery, as both used tramadol, as recommended by the Santa Casa Maceió antinociception guide
Summary
Total knee arthroplasty (TKA) is a highly successful operation in the treatment of degenerative knee changes and is in increasing demand worldwide due to the aging population and the need to preserve people’s quality of life. It involves extensive tissue trauma, which contributes to the occurrence of severe postoperative pain, and analgesia in this phase is of fundamental importance Zabeu, Migon, Junior [1]. Half of patients undergoing TKA experience severe pain after the procedure. Postoperative pain represents a time of physical and emotional distress, and negatively affects patient recovery Jokela et al [2]. There is release of catabolic hormones such as cortisol, glucagon, Copyright © All rights are reserved by Rogério Nascimento Costa
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