Abstract
Background: The most leading cause of perinatal and maternal deaths and morbidity in developed and developing countries like India is pregnancy related hypertensive disorders especially pre-eclampsia. PIH is defined as; in previously normotensive and normoproteinuric women, hypertension of >_ 140/90 mmHg with or without proteinuria measured on two occasions 6 hours apart after gestational age (20 weeks).Women with pregnancy related hypertensive disorders experience varied and altered lipid changes. Increased TG, low-density lipoprotein cholesterol (LDL-C), cholesterol and decreased high-density lipoprotein cholesterol (HDL-C) concentrations leading to dyslipidemia was found in majority of the studies.
 Aim: The study aims to evaluate predictor like maternal sr. lipid profile in 2nd trimester in pregnancy related hypertensive disorders.
 Objective: To evaluate the occurrence of normal maternal and altered maternal serum lipid profile serum lipid profile in 2nd trimester of pregnancy in pregnancy related hypertensive disorders and compare them .
 Materials and Methods: The design of the study will be prospective as well as observational conducted from September 2020 to august 2022 with an estimated sample size of 1000. Patients included were nnormotensive and non-proteinuric in second trimester (13-20 weeks of gestation). Subjects will be evaluated on the basis of preformed and pretested proforma consisting of history, clinical symptoms and presentation and investigations. Blood samples for serum lipid profile will be collected in plain bulb with aseptic conditions and analyzed at the biochemistry laboratory by enzymatic method.
 Expected Results: We expect that from our results, altered maternal serum lipid profile in 2nd trimester will be positively associated with pregnancy related hypertensive disorders.
Highlights
One of the most leading cause of perinatal and maternal morbid conditions as well as deaths in developed as well as developing countries is pregnancy related hypertensive disorders especially pre-eclampsia.PIH is defined as; in previously normotensive and normoproteinuric women, hypertension of >_ 140/90 mmHg after gestational age of 20 weeks with/without proteinuria measured on two different times 6 hours apart [1].The American College of Obstetricians and Gynaecologists (ACOG) has categorized pregnancy hypertensive disorders into four categories: gestational hypertension, where resting blood pressure (BP) is 140/90 mmHg or greater during the 20th gestation week; chronic hypertension, which develops before pregnancy or starts during gestational age till 20 weeks; preeclampsia.It is a continuous effort by obstetricians to recognize and if possible, foresee the risk involved in pregnancy
PIH is defined as; in previously normotensive and normoproteinuric women, hypertension of >_ 140/90 mmHg with or without proteinuria measured on two occasions 6 hours apart after gestational age (20 weeks).Women with pregnancy related hypertensive disorders experience varied and altered lipid changes
Increased TG, low-density lipoprotein cholesterol (LDL-C), cholesterol and decreased high-density lipoprotein cholesterol (HDL-C) concentrations leading to dyslipidemia was found in majority of the studies
Summary
One of the most leading cause of perinatal and maternal morbid conditions as well as deaths in developed as well as developing countries is pregnancy related hypertensive disorders especially pre-eclampsia.PIH is defined as; in previously normotensive and normoproteinuric women, hypertension of >_ 140/90 mmHg after gestational age of 20 weeks with/without proteinuria measured on two different times 6 hours apart [1].The American College of Obstetricians and Gynaecologists (ACOG) has categorized pregnancy hypertensive disorders into four categories: gestational hypertension, where resting blood pressure (BP) is 140/90 mmHg or greater during the 20th gestation week; chronic hypertension, which develops before pregnancy or starts during gestational age till 20 weeks; preeclampsia (raised BP and edoema or proteinururia).It is a continuous effort by obstetricians to recognize and if possible, foresee the risk involved in pregnancy. The American College of Obstetricians and Gynaecologists (ACOG) has categorized pregnancy hypertensive disorders into four categories: gestational hypertension, where resting blood pressure (BP) is 140/90 mmHg or greater during the 20th gestation week; chronic hypertension, which develops before pregnancy or starts during gestational age till 20 weeks; preeclampsia (raised BP and edoema or proteinururia). The most leading cause of perinatal and maternal deaths and morbidity in developed and developing countries like India is pregnancy related hypertensive disorders especially preeclampsia. PIH is defined as; in previously normotensive and normoproteinuric women, hypertension of >_ 140/90 mmHg with or without proteinuria measured on two occasions 6 hours apart after gestational age (20 weeks).Women with pregnancy related hypertensive disorders experience varied and altered lipid changes. Materials and Methods: The design of the study will be prospective as well as observational
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