Abstract
Evaluation of PPP2R5C gene expression in Iranian patients with B-Acute lymphoblastic leukemia and its association with clinical and laboratory findings
Highlights
PPP2R5C is one of the regulatory B subunits of protein phosphatase 2A (PP2A), which is a tumor suppressor
With regard to the critical functions of PPP2R5C we investigated the gene expression of this protein in Iranian patients with B-Acute Lymphoblastic Leukemia and its association with clinical and laboratory findings
PPP2R5C gene expression normalized against the internal gene, beta-2-microglobolin (β2M), by specific primers depicted in table 1
Summary
PPP2R5C is one of the regulatory B subunits of protein phosphatase 2A (PP2A), which is a tumor suppressor. PPP2R5C plays a critical role in cell proliferation, differentiation, and transformation Considering these vital functions, we investigate the gene expression in Iranian patients with B-Acute Lymphoblastic Leukemia (B-ALL) and its association with clinical and laboratory finding. There was no correlation between PPP2R5C expression and clinical and laboratory findings and FAB (French-American-British) subtype of patients. There was no significant correlation between PPP2R5C expression, clinical and laboratory finding and with FAB subtypes of patients. The opposing function of phosphatases and kinases is a more important mechanism involved in regulation of different signaling pathways, so aberrations in regulatory proteins of these mechanisms may be from significant causes of leukemia [5]. With regard to the critical functions of PPP2R5C we investigated the gene expression of this protein in Iranian patients with B-Acute Lymphoblastic Leukemia and its association with clinical and laboratory findings
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