Evaluation of povidone-lanoliim alcohol films by in vitro release of cortisol

Abstract

A series of films containing varying proportions of povidone K-30 and lanolin alcohol were evaluated for wettability, strength, and elastic properties. The drug release characteristics of these films were evaluated using cortisol (2.5% w w ), a topical anti-inflammatory agent. The incorporation of lanolin alcohol increased the contact angle of the films. The release of cortisol from the films in aqueous medium at 37° C declined with increasing proportion of lanolin alcohol. The drug release rate constant increased approximately linearly with the increase inpovidone content from 0–65% w w . The films with greater than 65% w w lanolin alcohol demonstrated a Q versus T 1 2 relationship as proposed by Higuchi. In povidone-rich films including film VI (58.5% w w povidone), pouidone possibly contributes to the rapid dissolution of cortisol.