Abstract
Background Mitochondrial ATP synthase, subunit c, isoform 3 (Atp5g3), encodes subunit 9 of a multisubunit enzyme that catalyzes the synthesis of ATP during oxidative phosphorylation. Each ATP synthase complex has multiple copies of subunit 9 in its transmembrane portion (Fo). While much is known about the molecular mechanisms and function of this complex in the mitochondrial membrane, the impact of variants in this complex and its connection to other pathways and human diseases and disorders is unknown.
Highlights
Mitochondrial ATP synthase, subunit c, isoform 3 (Atp5g3), encodes subunit 9 of a multisubunit enzyme that catalyzes the synthesis of ATP during oxidative phosphorylation
Materials and methods Using extensive phenotype and gene expression data sets in GeneNetwork, we generated correlations between variation in the expression of Atp5g3 in three tissues and traits that are related to alcoholism and metabolism/obesity
The correlation in expression levels between Atp5g3 and each of these partners are different in tissues and genes
Summary
Mitochondrial ATP synthase, subunit c, isoform 3 (Atp5g3), encodes subunit 9 of a multisubunit enzyme that catalyzes the synthesis of ATP during oxidative phosphorylation. Each ATP synthase complex has multiple copies of subunit 9 in its transmembrane portion (Fo). While much is known about the molecular mechanisms and function of this complex in the mitochondrial membrane, the impact of variants in this complex and its connection to other pathways and human diseases and disorders is unknown
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