Abstract
Experimental granulations were produced using aqueous and alcoholic solutions of polymeric celluloses, vinyls, acrylamides, pyrrolidones, oxazolidinones, and ethylene oxide condensation products. Products were compared to control formulations granulated with starch paste. Dextroamphetamine sulfate was employed in a preliminary dialysis and dissolution study in the presence of the polymers shown to be of value. The experimental products exhibited gloss equal or superior to coated tablets in many instances, and no drug binding or inhibition of release occurred. The polymer-bound granulations displayed excellent flow properties, were easily compressed into tablets of various degrees of hardness, were generally more resistant to friabilation than the control; some of the polymers produced tablets which had equal or superior disintegration times compared to the control.
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