Evaluation of Polyherbal preparation of Livina against Ethanol Induced Liver Dysfunction

Abstract

The present study was performed to evaluate the hepatoprotective activity of ployherbal preparation of livina against ethanol-induced hepatotoxicity in rats. Four groups of adult albino wistar rats were taken for the study. Rats were divided into four groups each containing 6 animals. Group first is normal group received the normal saline 10ml/kg for 21th days. Group second negative control this group received ethanol 12ml/kg bw per day is standard dose of this group is Silymarin (100mg/kg) daily for 21th days and in 21th day administered ethanol. Group third is standard dose of this group is Silymarin (100mg/kg) daily for 21th days and in 21th day administered ethanol. Silymarin and ethanol is administered orally. Fourth group is treated with ethanol + livina (Herbal capsule). The level of Serum Glutamic Pyruvic Transaminase Test (SGPT), Serum Glutamic-Oxaloacetic Transaminase Test (SGOT), alkaline phosphatase (ALP) and total bilirubin were determined to assay hepatotoxicity. Ethanol administration caused severe hepatic damage in rats as evidenced by elevated serum SGPT, SGOT, ALP and total bilirubin levels. The polyherbal preparation of livina and silymarin administration prevented the toxic effect of ethanol. The present study concludes polyherbal preparation of livina that has significant hepatoprotective activity against ethanol induced hepatotoxicity, which may be associated with its bioactive component.