Abstract
Cancer is a malignant abnormal growth of cells, one of the most dreaded and complex diseases. It concerns with several tempo spatial changes in cell composition, which finally lead to neoplasia. Various types of cancers have been reported. Chemotherapy, radiation, and/or surgery may cure them. Herbal remedies are supposed to be harmless as they cause fewer complications and are less likely to habitual. Antioxidant compositions of therapeutic plants show the anticancer activity and therefore, use of different proportions of the active components to formulate various standardized preparation with single or multiple components for their synergistic effects play a crucial role in curing cancer. Evaluation parameters to assess the in vitro anticancer activity includes Caspase-3, Caspase-9, alamar blue, LDH assay, XTT assay, sulforhodamine-B assay, MTT assay, DNA fragmentation assay, neutral red uptake cytotoxic assay, tryphan blue assay. Evaluation of dried extract or granules includes bulk density, tapped density, Carr’s index, Hausner’s ratio, angle of repose while the tablets evaluated by drug-excipient compatibility study by FT-IR, stability studies, hardness, thickness, weight variation, friability, disintegration time and dissolution test.
Highlights
Malignancy persists to distinguish the race and claims greater than 6 million leading cause of death in the human lives per year (Abdullaev, 2001)
Antioxidant compositions of therapeutic plants show the anticancer activity and use of different proportions of the active components to formulate various standardized preparation with single or multiple components for their synergistic effects play a crucial role in curing cancer
Evaluation of dried extract or granules includes bulk density, tapped density, Carr’s index, Hausner’s ratio, angle of repose while the tablets evaluated by drug-excipient compatibility study by FT-IR, stability studies, hardness, thickness, weight variation, friability, disintegration time and dissolution test
Summary
Malignancy persists to distinguish the race and claims greater than 6 million leading cause of death in the human lives per year (Abdullaev, 2001). Therapeutic plants have been utilized as medicine for individual diseases for a long time. The therapeutic importance of plants lays in some chemical components usually derivative metabolites that take them into being a specific physiological accomplishment on the human being. Active metabolites from plants are important source of novel drugs that are likely to lead to development in treatments of variety of cancers. The formulation prepared by plant extracts or complete plant material with appropriate excipients are known as Herbal formulations. Various in vitro and in vivo methods have been developed to determine the effectiveness of natural anticancer compounds. Tryphan blue dye exclusion assay, LDH (Lactic dehydrogenase) assay, MTT assay, XTT assay and Sulforhodamine B assay and many more are most commonly used for estimating anticancer properties of natural products from medicinal plants. Dried extract evaluation include determination of Bulk density, Tapped density, Carr’s index, Hausner’s ratio, Angle of repose while the tablets evaluated by Drug-Excipient Compatibility Study by FT-IR, Stability studies, Hardness, Thickness, Weight Variation, Friability, Disintegration Time, In vitro Dissolution test
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