Abstract
In this paper, a capillary coated with poly(glycidyl methacrylate) nanoparticles (PGMA NPs) was prepared and applied to construct a capillary electrophoresis (CE) enantioseparation system with glucosyl-β-cyclodextrin (Glu-β-CD) as a chiral selector. The PGMA NP coating can be easily introduced through a simple ring-opening reaction. Two basic drugs were used as models to evaluate the separation performance of the PGMA coating. Under the optimal conditions selected, the separation of the two enantiomers was obtained.
Highlights
The human body and the two enantiomers show different pharmacodynamics and pharmacokinetic properties, which means controlling the quality of the drug enantiomers is the key factor in the modern pharmaceutical industry
Very obvious spherical protrusions can be observed, which indicates that the PGMA nanoparticle coating has been successfully immobilized to the inner wall of the capillary
The migration time of racemic drugs all increase with the increase of Glu-β-CD concentration. The reason for this phenomenon may be the enhanced interaction between the chiral selector and the enantiomer led by local enrichment of Glu-β-CD in the PGMA nanocoating
Summary
The human body and the two enantiomers show different pharmacodynamics and pharmacokinetic properties, which means controlling the quality of the drug enantiomers is the key factor in the modern pharmaceutical industry. The induction of new type of materials to modify the inner wall of the capillary and enhance the selectivity and efficiency of CE has become a commonly used method [7, 8]. Mayer and Schurig reported the first chiral open tubular CEC system based on Chirasil-Dex- (permethyl-β-cyclodextrin chemically linked to dimethylpolysiloxane-) modified column for enantioseparation. This method was developed in 1992 [21]. Compared with the uncoated bare column system, the HKUST1 coating system has significantly improved separation for enantiomers [22]. The main influencing factors such as chiral selector concentration and background electrolyte (BGE) pH are systematically studied
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