Evaluation of plasmatic levels of CK-MB and C-Reactive Protein in brachicephalic dogs who have narin stenosis before and after diode laser rhinoplasty

Aguinaldo Francisco Mendes Junior,Nádia Regina Pereira Almosny,Ana Maria Barros Soares,Marina Ribeiro Hotz,Pâmela Cristina De Souza Duarte,Juliana Letícia Rosseto Marques,Gabriele Barros Mothé,Vivian Gomes Ferreira De Almeida,Gabriela Souza Leão Bezerra Dos Santos

doi:10.33448/rsd-v10i3.13211

Aguinaldo Francisco Mendes Junior, Nádia Regina Pereira Almosny + Show 7 more

Open Access

https://doi.org/10.33448/rsd-v10i3.13211

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Abstract

To evaluate the protective effect of rhinoplasty with diode laser on the cardiovascular system and in the reduction of the inflammatory state, CK-MB and PCR measurements were performed before and 30 days after the surgical procedure. Rhinoplasty using the diode laser promoted a significant reduction in plasma CK-MB and PCR levels, 30 days after its completion. No association was found between the pre-surgical plasma concentration of CK-MB and CRP and the degree of stenosis of the nostrils, race, age, sex and weight of the animals. A significant reduction in CK-MB was observed in dogs with severe stenosis, French Bulldog, one year old and over four years old, male and between 10 and 20 kg. Animals with severe stenosis, of the Pug breed, weighing less than 10 kg and three years of age exhibited a significant decrease in serum CRP values after surgery. As a result, the degree of stenosis of the nostrils, the breed, age, sex and weight of the animals did not influence the plasma concentration of NTpro-BNP, CK-MB and PCR in brachycephalic dogs. Rhinoplasty with diode laser has been shown to be effective in reducing the plasma concentration of the natriuretic peptide CK-MB and CRP in dogs with brachycephalic syndrome, showing that the procedure has a protective effect on the cardiovascular function of these animals and is also effective in reducing inflammatory biomarkers.

Highlights

The brachycephalic syndrome is directly linked to obstructive processes that occur due to important anatomical deformities of the anterior airways (Honey, 2017; Packer, O’Neill, Fletcher, Farnworth, 2019) These changes impact the physiological functions of the respiratory, cardiovascular and digestive systems, significantly compromising the well-being and quality of life of these animals (Fawcett et al, 2019).It is known that the earlier the resistance to air entry, the greater the inspiratory effort (Koch, Arnold, Hubler, Montavon, 2003; Meola, 2013)
Regarding the degree of stenosis of the nostrils, of the 30 animals in the study, six (20%) exhibited stenosis of the nostrils classified as grade 2 and 24 (80%) as grade 3
A significant difference was found in creatinophosphokinase - MB (CK-MB) concentrations before and after surgery, showing that rhinoplasty with diode laser was effective in decreasing this biomarker in brachycephalic dogs

Summary

Introduction

The brachycephalic syndrome is directly linked to obstructive processes that occur due to important anatomical deformities of the anterior airways (Honey, 2017; Packer, O’Neill, Fletcher, Farnworth, 2019) These changes impact the physiological functions of the respiratory, cardiovascular and digestive systems, significantly compromising the well-being and quality of life of these animals (Fawcett et al, 2019).It is known that the earlier the resistance to air entry, the greater the inspiratory effort (Koch, Arnold, Hubler, Montavon, 2003; Meola, 2013). The brachycephalic syndrome is directly linked to obstructive processes that occur due to important anatomical deformities of the anterior airways (Honey, 2017; Packer, O’Neill, Fletcher, Farnworth, 2019) These changes impact the physiological functions of the respiratory, cardiovascular and digestive systems, significantly compromising the well-being and quality of life of these animals (Fawcett et al, 2019). Bilateral nostril stenosis, being the most anterior anatomical alteration, is an important point of airway obstruction, strongly increasing inspiratory overload (Koch, Arnold, Hubler & Montavon, 2003). It is believed that cardiovascular changes may appear in dogs brachycephalic disease secondary to obstructive disease. Clinical signs, such as syncope, arrhythmias, cyanotic mucous membranes, dyspnea and exercise intolerance can be found (Camacho, 2006). Due to the respiratory syndrome, these episodes may occur in the brachycephalics (Hoffman, 2007)

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