Abstract
Introduction and Aim: Activated autologous platelet-rich plasma (aaPRP) is becoming a popular therapy to accelerate healing in the field of plastic surgery. Platelets, which are abundant in aaPRP, can release many growth factors including platelet-derived growth factor (PDGF) and vascular endothelial growth factor (VEGF). This study aims to examine the plasma levels of PDGF and VEGF in healthy subjects after intravenous administration of aaPRP.
 
 Materials and Methods: Nine healthy patients with no prior history of metabolic disease were divided into two groups (control and experiment group). The treatment group which consists of six patients received intravenous aaPRP treatment. The preparation of aaPRP starts with the collection of 24 mL of whole blood in sodium citrate tubes followed a two-step centrifugation procedure and subsequent chemical activation. aaPRP was then administered intravenously to patients. Meanwhile, the control group received no intervention. Venous blood samples were taken before and one week after the treatment and the plasma PDGF and VEGF levels were determined by enzyme-linked immunosorbent assay (ELISA).
 
 Results: The treatment group showed statistically significant increase in VEGF after 7 days compared to before aaPRP administration. However, the change in PDGF levels of the treatment group was unnotable.
 
 Conclusion: The present findings indicate that intravenous administrations of activated aaPRP may increase plasma VEGF level up to 1 week after aaPRP administration.
Highlights
Introduction and AimActivated autologous platelet-rich plasma is becoming a popular therapy to accelerate healing in the field of plastic surgery
The present findings indicate that intravenous administrations of activated Activated autologous platelet-rich plasma (aaPRP) may increase plasma vascular endothelial growth factor (VEGF) level up to 1 week after aaPRP administration
Our previous study showed that intravenous (IV) administration of aaPRP combined with stromal vascular fraction (SVF) was safe to treat 421 patients of various pathologies and demographics [10]
Summary
Introduction and AimActivated autologous platelet-rich plasma (aaPRP) is becoming a popular therapy to accelerate healing in the field of plastic surgery. Autologous activated platelet-rich plasma (aaPRP) is processed autologous plasma It is enriched in platelet concentration, it is abundant in bioactive molecules such as growth factors in comparison to whole blood [1, 2]. These molecules exert numerous positive effects on the body and because of its potential benefit, aaPRP has been of great academic interest over the past few years [1, 3]. It was reported that both PRP and aaPRP improved tendon healing rates, pain levels, and functional outcomes significantly higher than platelet-rich fibrin (PRF; 8); while another study demonstrated that PRP in other preparation methods, such as advanced platelet-rich fibrin (A-PRF) and concentrated growth factors (CGF), stimulated periosteal cell proliferation [11]. A recent meta-analysis has documented various applications of CGF, ranging from facial rejuvenation to cartilage grafting and facial peripheral nerve injury [12]
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