Abstract
IntroductionThe goal of this study is to investigate the association between diagnosis and severity of coronary artery disease (CAD) and Asprosin level.MethodsPatients diagnosed with CAD who underwent conventional coronary angiography for the first time were included in the present study. The patients were divided into four groups, each consisting of 20 individuals, as medical group, single coronary lesion group, double coronary lesion group, and multiple coronary lesions group. Serum Asprosin values and Gensini scores of the groups were compared in terms of compliance.ResultsIn this study, Asprosin values were found to be significantly higher in the multiple coronary lesions group than in the medical, single coronary, and double coronary lesion groups (P<0.05). In the double coronary lesion group, Asprosin values were significantly higher (P<0.05) than the in the medical and single coronary lesion groups. It was also found that Asprosin values did not differ at significant levels in the medical and single coronary lesion groups (P>0.05). It was determined that the increases in Asprosin values and Gensini scores were compatible with each other.ConclusionThe present study showed that the increases in serum Asprosin levels, along with the increases in the number of coronary arteries with critical stenosis, might be a marker in diagnosing and determining the severity of CAD.
Highlights
The goal of this study is to investigate the association between diagnosis and severity of coronary artery disease (CAD) and Asprosin level
Patients were divided into four groups each consisting of 20 individuals: patients who had normal coronary angiography findings or who did not have critical lesions, which were included in the medical group; patients with a single critical coronary artery lesion; and patients with double and multiple critical coronary artery lesions
Asprosin and Gensini scores were calculated separately in the present study, and the compliance between them was compared with the Bland-Altman plot method
Summary
The goal of this study is to investigate the association between diagnosis and severity of coronary artery disease (CAD) and Asprosin level. Coronary artery disease (CAD) is a clinical condition that is characterized by the stenosis and obstruction of the coronary arteries caused by atherosclerosis. Acute myocardial infarction and mortality might occur with the progression of the disease[1]. 18 million deaths occur on an annual scale because of cardiovascular diseases, especially CAD. CAD ranks second in mortality reasons after traumatic deaths on a global scale. Deaths because of CAD are increasing rapidly in developing countries[2,3]. Diagnosis and determining the prevalence of atherosclerosis play important roles in reducing cardiovascular diseases and related deaths[4]
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