Abstract
The importance of variations in the activity of placental steroidogenic enzymes in regulating estrogen production has been investigated. Maternal estrogen excretion during the final week of gestation and placental aromatase and steroid 3-sulfatase activities were determined in a series of 22 normal and 39 complicated pregnancies. There were no significant correlations between estrogen excretion and enzyme activities. The data do not confirm previous reports that placental aromatizing capacity is reduced in diabetes and toxemia. It is concluded that variations in these enzyme activities, as determined in vitro, are largely independent of maternal disease and do not provide a general mechanism for regulation of estrogen production.
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