Evaluation of physico-chemical properties of acrylic resin hydrogel and their application to transdermal delivery system

Abstract

Recently, many attempts have been made to use hydrogels of various polumers as delivery systems of various drugs and bioactive materials to prolong and control their pharmacological activities. In this study, we have evaluated the physico-chemical properties of methacrylic acid-methacrylic acid methyl ester copolymer (Eudispert mv), a acrylic resin hydrogel, and its application to transdermal delivery system. In the dissolution tests, the release rate of salicylic acid (SA) and sodium salicylate (Sod. SA) were faster than lidocain (LD) and lidocain-HCl (LD-HCl). As the concentration of Eudispert mv polymer increased, the extensibility of Eudispert mv hydrogel decreased, whereas the swelling ratio increased. The more NaOH and polymer concentration increased, the more osmotic pressure linearly increased. The skin permeation of Sod. SA, an acidic model drug, was remarkably enhanced by Eudispert mv hydrogel. All fatty acids, except for Sod. glycolate, dramatically increased the skin permeation flux in Eudispert mv hydrogel containing LD-HCl, a basic model drug. Consequently, it is suggested that Eudispert mv hydrogel may be used as potential transdermal delivery vehicle.