Abstract
Leonurus japonicus is rich in bioactive compounds especially polysaccharide. Single factors test and response surface methodology were used to study the optimum conditions for ultrasonic - assisted extraction of polysaccharide from L. japonicus, and its physiochemical and DPPH scavenging activities also were evaluated. The optimal conditions as underpinned by this paper is as follow: extraction temperature of 70 �C, extraction time of 50 min and extraction power of 210W. The polysaccharide of L. japonicus was shown to be a non-reducing sugar and to exhibit DPPH scavenging activity to an extent. The polysaccharide structures were studied using SEM, AFM, and FT-IR. It showed L. japonicus polysaccharide had been having more than one chains which were branched and entangled with each other. and existed a broad band wavelength of 2925.64, 1635.06, 1539.7, 1046.73, and 477.86 cm-1. The study indicated that L. japonicus may have a beneficial use to the medical and food industries.
Highlights
Leonurus japonicus is employed in the treatment of several ailments among the 50 fundamental Chinese medicine
The effect of the different time (30, 40, 50, and 60 min) on the yield of polysaccharide was examined with the other extraction parameters such as temperature, power and solid-liquid ratio set at 70oC, 210 watt and 1:15 respectively
This could be due to longer extraction time which could result to lower yield of polysaccharide [34]
Summary
Leonurus japonicus is employed in the treatment of several ailments among the 50 fundamental Chinese medicine. Some of its use in Chinese herbal medicine include edema dispel, regulation of menstrual disorder, diuretics and invigorating blood circulation [1]. The active components of L. japonicus as conforming to modern pharmacological studies such as bioactive polysaccharides, have been reported to exhibit some pharmacological properties such as cardio protective, anticancer, antioxidant, analgesic and neuroprotective, antibacterial as well as have effect on women uterus [2]. It is currently being used as facial masks or ointments and in food products, accompanied with other components to treat skin disease as well as help in activation of blood circulation [3]. The replacement of synthetic antioxidant with naturally occurring antioxidant is increasing due to the side effects associated with synthetic antioxidant such as increased risk of cancer [4,5,6,7,8,9,10,11,12,13,14,15]
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