EVALUATION OF PERIPHERAL INFLAMMATION PARAMETERS IN ADOLESCENTS WITH SUICIDE ATTEMPTS

Abstract

OBJECTIVE: Haematological parameters are peripheral inflammation markers that can be used to demonstrate the relationship between psychopathology and inflammation. In this study, we aimed to compare adolescents who attempted suicide with healthy adolescents in terms of haematological parameters.MATERIAL AND METHODS: The haemogram records of 765 adolescents admitted to the Paediatric Emergency Service between October 2018 and March 2020 were retrospectively evaluated. The control group was created from the haemogram records of adolescents who had similar age and sex characteristics, who had been examined in paediatric outpatient clinics during the above-mentioned period and who did not have any organic or psychopathological disorder. After implementation of the exclusion criteria, 95 adolescents with suicide attempts and 95 healthy adolescents were included in the study. The case and control groups were statistically compared in terms of neutrophil/lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), monocyte/lymphocyte ratio (MLR), mean platelet volume (MPV) and red cell distribution width (RDW) parameters.RESULTS: It was found that in adolescents with suicide attempts, NLR and MLR values were significantly higher than in the control group. There was no significant difference between the groups in terms of other parameters. In terms of NLR and MLR parameters, there was no statistical difference among the three subgroups of the case group separated according to the psychiatric diagnoses. However, NLR was found to be significantly higher in comparison with the control group of these three subgroups.CONCLUSIONS: The NLR and MLR parameters of adolescents who attempted suicide were higher than those of the control group. There is a need for more comprehensive studies on the evaluation of inflammatory parameters in adolescents who have attempted suicide.