EVALUATION OF PERIPHERAL AND CENTRAL ANALGESIC EFFICACIES OF AYURVEDIC NEW FORMULATION FOR AMAVATA DISEASE IN ANIMAL MODEL THROUGH WRITHING TEST AND TAIL -FLICK IMMERSION TEST IN MICEMODEL- AN ANIMAL EXPERIMENTAL STUDY.

Abstract

Background: Rheumatoid arthritis (RA) is a chronic inflammatory disorder, it is the most common persistent inflammatory arthritis, occurring throughout the world and in all ethnic groups. This is the most marked in those with severe diseases, with a reduction in expected lifespan by 8-15 years. Around 40% of RA pa-tients are registered disable within 3 years, around 80% are moderately to severely disables within 20 years, and 25% will require a large joint replacement. Functional capacity decreases most rapidly at the beginning of disease and the functional status of patients within their 1st year of RA is often predictive of long-term out-come(1). Aim: In research field RA need more attention for deep research due to, firstly its unbearable symptoms and secondary complication and secondly in modern science there are medicines available for temporary manage-ment purpose but with lot of adverse reaction. RA is a non-curable disease, in Ayurveda, RA can be corelated with Amavata disease (Rheumatoid arthritis). Methodology: In this present study It has been taken up to see the efficacy of new combined Ayurvedic formu-lation i,e combination of Stem of Asthishrinkhala (Cissus quadrangularis L), bulb of Sunthi (Zingiber offici-nale Roscoe) and bulb of Rasona (Allium sativum L) with (1:1:1) ration for better management with less side effects. This research firstly done on animal to evaluate central and peripheral activity of research drug, through Writhing Test and Tail -flick immersion test in Mice model.