Evaluation of Paste Containing Gentamicin, Amoxicillin and Metronidazole in Endodontic Treatment of Primary Molars in Vivo.

Abstract

To evaluate and compare the efficacy of gentamicin, amoxicillin and metronidazole (GAM) antibiotic paste in noninstrumentation and instrumentation techniques in infected primary molars. Sixty primary molars in children of 4 to 8 years were selected and divided into four groups: teeth without any periapical or furcation involvement undergoing pulpectomy by noninstrumentation (Group N1) and instrumentation (Group N2) technique using GAM antibiotic paste; teeth with periapical or furcation involvement undergoing pulpectomy by noninstrumentation (Group R1) and instrumentation (Group R2) technique using GAM antibiotic paste. Regular follow-up at 3, 6 and 12 months was carried out for each group and all the clinical and radiographic changes were evaluated statistically using SPSS software. The level of significance was set to P < 0.05. Overall, 73.3% of success was observed in Group N1, 71.4% in Group N2, 86.7% in both Group R1 and Group R2 (P = 0.003). The GAM lesion sterilisation and tissue repair (GAM-LSTR) technique can be an alternative to conventional pulpectomy.