Abstract
SummaryOxisuran, 2-[(methylsulfinyl)-acetyl]pyridine, is a new immunosuppressive agent which is reported to act as a differential inhibitor of cell-mediated immunity. Published studies have shown that it prolongs skin graft survival in mice, rats, and dogs. The present experiments demonstrate that it is also an immunosuppressive agent in the transplantation of other organs. Oxisuran produced significant prolongation of functional survival time of heterotopic cardiac allografts in rats. In addition, using a rat kidney-transplant model, there was significant reduction of in vitro cytotoxicity of thoracic duct cells against target kidney cells, whereas the humoral antibody response was unchanged.We thank Dr. H. H. Freedman of Warner-Lambert Research Institute, Morris Plains, NJ, for helpful advice and data concerning oxisuran and for generously supplying us with this immunosuppressive agent.
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