Abstract
Evaluation of Oxidative Stress Parameters in Liver in Pentylenetetrazole - Induced Acute and Chronic Epilepsy Model in Rats
Highlights
Epilepsy occurs due to periodic and spontaneous excessive electrical discharges of cerebral, cortical and subcortical neurons
There was no significant difference between chronic epileptic model group and control group (p> 0.05)
Serum AST levels of the chronic epileptic model and control group were significantly lower than the acute epileptic model group (p
Summary
Epilepsy occurs due to periodic and spontaneous excessive electrical discharges of cerebral, cortical and subcortical neurons. It is often used to model the occurrence of animal epilepsy and evaluate the efficacy of antiepileptic agents. It is one of the drugs commonly used in the formation of generalized tonic-clonic epileptic seizures [3]. Increased oxidative stress in the central nervous system has been shown to increase in various experimental epilepsy models and electroshock models [6] such as the amygdala burning model [7], kainic acid model [8], PTZ model [9], sound stimulation (switching) model [10]. The aim of this study was to evaluate the levels of oxidative injury in chronic and acute epilepsy model by measuring AST and ALT enzyme levels from serum samples and CAD, TBARS and SOD levels in liver tissues
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