Abstract
Simple SummaryThe present study evaluated oxidative and antioxidant status in dairy cows with Left Displacement of the Abomasum (LDA), an economically important postpartum disease in cattle. The oxidant capacity of plasma measured with a test fo reactive oxygen metabolites, the d-ROMs test, was significantly higher and the plasma biological antioxidant potential (BAP), measured with the BAP test was lower in the LDA group compared with the control group. Oxidative status was assessed using an arbitrary index obtained from the ratio between d-ROMs and BAP and the results showed that cows with LDA experience an imbalance between oxidants and antioxidants.Left Displacement of the Abomasum (LDA) is a condition that occurs in high-producing postpartum dairy cows and it causes economic losses. Studies performed in the last decade indicate that adult dairy cows experience oxidative stress. Increasing interest in the role of oxidative status in ruminant medicine has emphasized the need to develop reliable methods to assess it. A few studies have evaluated the relationship between LDA and oxidative status, mostly through the determination of single parameters of oxidation and the determination of antioxidant status separately, with contrasting results. The aim of this study was to assess the oxidative status by the measurement of Reactive Oxygen Metabolites with d-ROMs and Biological Antioxidant Potential BAP and the calculation of the Oxidative Status index in 74 multiparous dairy cows with LDA. Each case was matched with a control herdmate. The amount of free oxygen radicals in plasma samples was determined using the d-ROMs test, the concentration of antioxidants was measured using the BAP test and the Oxidative Status index was also calculated. The concentration of d-ROMs was significantly higher in the study group compared to the control group (179 ± 37.7 U CARR and 158 ± 23.0 U CARR, respectively), while the concentration of BAP was significantly lower in the study group than in the control group (2156 ± 98.1 µmol/L vs. 2558 ± 108.5 µmol/L). The Oxidative Status index value was significantly higher in cows with LDA than in healthy cows (8.3 ± 1.51 vs. 6.2 ± 0.76). The results of this study indicated that an inbalance between oxidants and antioxidants occurred in cattle with LDA.
Highlights
Left Displacement of the Abomasum (LDA) is a condition that occurs primarily in high-producing postpartum dairy cows [1]
The results showed a significant elevation of d-ROMs and Oxidative Status index (OSi) and a significant reduction of in LDA cows, confirming that LDA is linked to shifts in oxidative status [18,19,20,23]
To the best of our knowledge, there is a limited number of studies on the determination of oxidative status using d-ROMs and biological antioxidant potential (BAP) and the calculation of OSi in ruminants [28,29,30] and, in oxidative status using d-ROMs and BAP and the calculation of OSi in ruminants [28,29,30] and, in particular, these tests have never been used in cows with left abomasal displacement
Summary
Left Displacement of the Abomasum (LDA) is a condition that occurs primarily in high-producing postpartum dairy cows [1]. LDA causes economic losses related to direct (correction, medication, discarded milk, etc.) and indirect (decreased productive and reproductive performances, increased risk of removal from the herd, etc.) costs [2]. It occurs predominantly within the first month of lactation [3], and more than 50% of cases are diagnosed in the first and second week postpartum [4,5,6]. Cows experience metabolic stress as energy demands overtake energy intake, so animals undergo a state of negative energy balance (NEB) [7]. Studies performed in the last decade indicate that adult dairy cows experience OS around the time of calving [11,12]
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