Evaluation of oxidative stress in cigarette smoking peoples before and after the treatment with vitamin c in Holley Kerbala

Abstract

The purpose of this study was to estimate some biochemical parameters in smoker peoples before and after the treatment with vitamin C. The study carried out in kerbala province from October 2018 to January 2019. Fifty male volunteers participated in this study, the volunteers was smoked twenty cigarrete daily for twenty years. The blood was drawn from smokers before the treatment and after the treatment (two months) with vitamin c. All chemical analysis is measured by medical chemo analyzer instruments. There was a significant increase in Malondialdehyde ( MDA), Aspartate aminotransferase( AST), Alanine aminotransferase (ALT), Alkaline phosphatase (ALP), Total Bilirubin, urea and creatinine and in smoking peoples as compared to non smoker groups, at the same time there was significant decrease in superoxide dismutase (SOD),catalase (CAT) activities in smoking groups as compared to control group, however after treatment the smokers with vitamin C the biochemical changes return near to normal values. We concluded the Cigar rete has adverse effects on liver and kidney and increase the oxidative stress in humans, vitamin c decrease the oxidative stress in smoker persons due to have the potent antioxidant effect.