Abstract
Objective: to study the redox status of normal colon and aberrant crypts formed in azoxymethane induced colon cancerous fischer rats. Methods A total of 16 five-week-old male Fisher 344 rats (Rattus norvegicus), weighing approximately 90–100 grams were housed individually in plastic cages with wood-chip bedding. The animals were acclimatized for 1 week and fed with an American Institute of Nutrition (AIN-93G) diet ad libitum. Their protein oxidation, DNA damage, lipid peroxidation and antioxidants, glutathione (GSH), and antioxidative enzymes in serum were detected. Results The levels of protein oxidation Sand lipid peroxidation were significantly higher in the study group than in the control group (P<0.01). However, the mean serum level of MDA and conjugated diene was lower in the study group than in the control group (P<0.01). The activity of antioxidative enzymes was significantly decreased in the study group compared to control group (P<0.01). Conclusion Colorectal cancer is associated with oxidative stress, and assessment of oxidative stress and given antioxidants is important for the treatment and prevention of colorectal cancer.
Highlights
Zinc is a trace element necessary for a variety of physiological and biochemical functions, including the integrity of the intestinal barrier and gut-associated immune function, reduction of oxidative stress and inhibition of apoptosis (Skrajnowska & Bobrowska-Korczak, 2019; Gombart et al, 2020)
This study was performed according to the guidelines approved by the Institutional Animal Care and Ethics Committee (IACEC) of the National Institute of Nutrition, Indian Council of Medical Research, Hyderabad
All the rats treated with AOM developed Abberent Crypt Foci (ACF), whereas no evidence of ACF could be detected in the colons of control animals
Summary
Zinc is a trace element necessary for a variety of physiological and biochemical functions, including the integrity of the intestinal barrier and gut-associated immune function, reduction of oxidative stress and inhibition of apoptosis (Skrajnowska & Bobrowska-Korczak, 2019; Gombart et al, 2020). The mechanism of intestinal absorption of zinc was partially elucidated (Maares & Haase, 2020).Because CRC treatment plan needs to consider nutritional responses towards anti-cancer drugs based on their biological and genetic characteristics, a possible association with zinc in cancer treatment requires attention. There is a clear association between zinc and risk of CRC. Intervention plan in this type of cancer needs to consider nutritional responses towards anti-cancer drugs based on their biological and genetic characteristics; a possible association with zinc in cancer treatment requires attention. The analysis of Zn biomarkers levels could provide new biological insights applied in prevention, molecular diagnosis, prognosis and treatment of CRC (Mehta et al, 2010; Rahman et al, 2019)
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