Abstract
Interleukin-6 (IL-6) can inhibit growth of a variety of tumors including B16 routine melanoma. IL-6 levels increase with age and after ovariectomy or menopause. The adrenal androgen, dehydroepiandrosterone sulfate (DHEAS), can lower serum IL-6 levels in aged mice. Therefore, we hypothesized that ovariectomy would induce elevations of serum IL-6 capable of inhibiting B16 melanoma growth in mice. Additionally we postulated that DHEAS would be able to reverse the ovariectomy-induced increase in IL-6, thus abrogating IL-6’s antitumor effect.
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