EVALUATION OF ORO-DISPERSIBLE TABLETS (ARTEMETHER- LUMEFANTRINE AND AMOXICILLIN TRIHYDRATE) USED FOR SOME COMMON CHILDHOOD DISEASES (MALARIA AND PHEUMONIA)

Abstract

Background: Generic substitution of a brand of medicine for others, with the hope that they have the same therapeutic effect is difficult for health care providers and consumers.
 Aim: This study was able to evaluate the authenticity of label claim of eight samples of artemether-lumefantrine and two samples of amoxicillin trihydrate tablets available at Ogige market Nsukka and Ogbete main market, Enugu.
 Method: The following tests were carried out; hardness, friability, modified disintegration time, wetting time, water absorption ratio and weight uniformity. The compliance of each sample to the United States Pharmacopoeia (USP) requirements were recorded.
 Results: The friability test showed that all the tablets passed the test with less than 1% friability loss. The mean hardness ranged from 1.65±0.47 to 5.35±0.67 kgf for artemether-lumefantrine tablets, while that of amoxicillin trihydrate tablets ranged from 4.00±0.93 to 6.10±0.91 kgf respectively. The tablet diameter and mean thickness of artemether-lumefantrine tablets ranged from 9.00±1.53 to 11.00±1.0 mm and 2.00±1.15 to 4.00±1.53 mm respectively, while that of amoxicillin trihydrate ranged from 8.00± 0.9 to 10.00±1.0mm and 3.00±2.08 to 4.00±1.53mm respectively. The disintegration time of artemether-lumefantrine tablets ranged from 1.50±0.1 to 3.52±0.01 min and 2.06±0.02 to 3.30±0.03 min for amoxicillin trihydrate respectively. The study discovered that several generic brands of artemether-lumefantrine and amoxicillin trihydrate tablets in Nigeria could be sub-standard products.
 
 Peer Review History: 
 Received: 28 June 2022; Revised: 1 August; Accepted: 5 September, Available online: 15 September 2022
 Academic Editor: Prof. Dr. Gorkem Dulger, Duzce University, Turkey, gorkemdulger@yandex.com
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 Received file: Reviewer's Comments:
 Average Peer review marks at initial stage: 5.5/10
 Average Peer review marks at publication stage: 7.0/10
 Reviewers:
 Dr. Mohammad Bayan, Faculty of Pharmacy, Philadelphia University, P.O. Box: 1 Philadelphia University 19392 Jordan, mbayan01@qub.ac
 Dr. Sally A. El-Zahaby, Pharos University in Alexandria, Egypt, sally.elzahaby@yahoo.com
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