Evaluation of Organ-At-Risk (OAR) Sparing in Vaginal Cuff Boost Treatment for Endometrial Cancer using Stereotactic Body Radiotherapy (SBRT) and Brachytherapy

Selcuk Demiral

doi:10.19080/ctoij.2017.07.555717

Abstract

Evaluation of Organ-At-Risk (OAR) Sparing in Vaginal Cuff Boost Treatment for Endometrial Cancer using Stereotactic Body Radiotherapy (SBRT) and Brachytherapy

Highlights

Postoperative radiotherapy (RT) followed by vaginal cuff brachytherapy boost is used to prevent recurrences in the vaginal cuff in endometrial cancer management [1]. 8-year vaginal cuff local control rates for patients with endometrial carcinoma were reported to be 85% with surgery alone,96 % with adjuvant pelvic RT alone and combined pelvic RT + brachytherapy has yielded a local control rate of 97.3% in the studies by Creutzberg et al & Mandell et al [2,3]
We evaluated target and critical organ doses with conventional brachytherapy and Stereotactic Body Radiotherapy (SBRT) in our patients receiving vaginal cuff boost after external pelvic RT for endometrial cancer
We compared 2-D brachytherapy boost and SBRT boost with the same dose and fractionation with respect to target, bladder and rectal point doses in endometrial cancer patients

Summary

Introduction

Postoperative radiotherapy (RT) followed by vaginal cuff brachytherapy boost is used to prevent recurrences in the vaginal cuff in endometrial cancer management [1]. 8-year vaginal cuff local control rates for patients with endometrial carcinoma were reported to be 85% with surgery alone,96 % with adjuvant pelvic RT alone and combined pelvic RT + brachytherapy has yielded a local control rate of 97.3% in the studies by Creutzberg et al & Mandell et al [2,3]. 8-year vaginal cuff local control rates for patients with endometrial carcinoma were reported to be 85% with surgery alone,96 % with adjuvant pelvic RT alone and combined pelvic RT + brachytherapy has yielded a local control rate of 97.3% in the studies by Creutzberg et al & Mandell et al [2,3]. Postoperative vaginal cuff boost radiotherapy may pose the risk of treatment related toxicity due to intimate association of critical organs with the high-dose region [4]. We evaluated target and critical organ doses with conventional brachytherapy and SBRT in our patients receiving vaginal cuff boost after external pelvic RT for endometrial cancer.

Objectives

Methods

Results

Discussion

Conclusion