Abstract
Background:Postoperative nausea and vomiting is one of the most common side effects associated with surgical procedures.Objectives:The aim of this study was to determine the effect of ginger on intensity of nausea and vomiting after surgical procedures.Patients and Methods:This study was a randomized, double blinded, clinical trial. 160 eligible patients were randomly assigned into experimental or placebo groups. The experimental group received 4 capsules containing 250 mg ginger and placebo group received 4 placebo capsules 1 hour before surgery. The severity of nausea and vomiting was measured at 2, 4, 6 hours post operation using visual analogue scale and a structured questionnaire. The data were analyzed by independent t - test, Mann-Whitney U test, chi –square and GEE using SPSS 16 and STATA version 11.Results:Mean nausea score at 2 hours post operation was significantly lower in the experimental group (P= 0.04). Mean nausea score at 4 and 6 hours post operation was lower in the experimental group; however, there was no significant difference between the groups at any time post operation. The frequencies of nausea in the experimental group at 2 and 6 hours post operation were lower than that in the placebo group, however, at 2 hours post operation, it was borderline significant (P = 0.05) There was no significant differences between two group in the intensity of vomiting at any time.Conclusions:Use of ginger was effective at decreasing postoperative nausea. Ginger could be used as a safe antiemetic drug at post operation.
Highlights
Postoperative nausea and vomiting is one of the most common side effects associated with surgical procedures
160 patients, 97 male (60.6%) and 63 female (39.4%) were studied. 45 patients(55.6%) in intervention group and 52 patients (56.8%) in placebo group were male. participants in the two groups were analyzed for characteristics such as age, systolic blood pressure, anesthesia duration and type of surgery and no statistically significant difference was seen (Table 1)
The average nausea score 2 hours after surgery was lower for ginger using patients (2.9 ± 2.1) than placebo group (3.5 ± 1.9). the average nausea score four and six hours after surgery was lower for ginger using patients than placebo group but no statistically significant difference was seen in any hour. the average numbers of nausea in ginger using patients was lower than placebo group two, four and six hours after surgery but this difference was marginally significant (P = 0.053) 2 hours after surgery (Table 2)
Summary
Postoperative nausea and vomiting is one of the most common side effects associated with surgical procedures. Results: Mean nausea score at 2 hours post operation was significantly lower in the experimental group (P = 0.04). Surgery and anesthesia, associated with innovation of recent drugs and methods, resulted in advancement in patient care These methods have some side effects including Intestinal paralysis, ileus, nausea, and vomiting [1]. Postoperative Nausea and vomiting is one of the most common complications of surgery, and usually occurs after any type of anesthesia [2]. This complication may occur up to 24 hours after the surgery and in 20-30% of patients. Uncontrolled nausea and vomiting, leads to delay in patient’s discharge, increased treatment costs, and decreased patient satisfaction [2]
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