Abstract
Recently, a dialysis-like filtration device has been devised to remove the red blood cells infected with the malaria parasite from whole blood using magnetic separation techniques. The capturing efficiency of this process depends on many interrelated design variables and constraints such as magnetic pole array pitch, channel height, length and flow rate. In this study, these parameters are varied in several common optimization algorithms, so as to minimize the channel length while maximizing the capturing efficiency. The equations of motion are solved numerically to predict the trajectories of the infected cells within an idealized rectangular micro-channel incorporating periodic high gradient magnetic poles. The channel length of the optimized design is obtained, together with the associated capturing efficiency. The optimization of the channel geometry and flow rate improves the efficiency of the device.
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