EVALUATION OF OPTIC DISK AND MACULAR VASCULARITY CHANGES IN CRVO USING OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY.

Abstract

To quantify changes in optic disk and macular vasculature in patients with central retinal vein occlusion using optical coherence tomography angiography and detect its correlation with visual acuity. The study included 20 eyes of 20 patients with treatment-naive central retinal vein occlusion and 20 age-matched controls. Optical coherence tomography and optical coherence tomography angiographywere performed on the macula and optic disk. Central 1-mm subfield foveal thickness was measured. Vessel densities (VD) of superficial and deep macular capillary plexuses with whole disk VD, inside disk VD, and radial peripapillary capillary plexus were analyzed. Macular ischemia was evaluated by fundus fluorescein angiography. Visual acuity was correlated with measured parameters. All measured macular and disk VDs differed significantly between cases and controls except inside disk VD. Visual acuity showed a highly significant negative correlation with whole disk VD ( P = 0.005) and radial peripapillary capillary ( P = 0.002), borderline correlation with central subfield foveal thickness ( P = 0.06), and insignificant correlation with macular VDs. Radial peripapillary capillary VD showed a significant correlation with deep parafoveal ( P = 0.04), and superficial and deep perifoveal VDs ( P = 0.01). Optic disk VD could provide more accurate indication of retinal blood supply than macular VD in cases of central retinal vein occlusion with severe macular edema.