Abstract
The Copaiba oil-resin (Copaifera sp.) is widely used in folk medicine, especially as a healing, antiinflammatory, antiseptic, to treat ulcers and skin diseases. Increased gastric emptying was observed with oilresin of Copaifera langsdorfii, highlighting those others species from the genus of Copaifera can act over the gastrointestinal tract. This study evaluated the activity of the Copaifera sp oil-resin on gastric emptying in Rattus novergicus. Eighteen male rats were fasted for 24h and orally received Tween-80 and Copaiba oil-resin 100 and 200 mg/kg; one hour later they all received phenol red (PR) 0.5 mg/mL. Then, the parts of gastrointestinal tract (stomach and intestine) were analyzed. The results showed that Copaifera sp oil-resin at 200 mg/kg increased the gastric emptying in Rattus novergicus.
Highlights
According to Copaiba’s biologic classification, this plants belongs to Leguminosae family, subfamily Caesalpinoideae, genus Copaifera (Brito, 2000; Cascon, 2004; Maciel, 2002; Veiga Junior, 2005; Oliveira, 2006), and there is 72 species identified (Index Kewensis, 1996)
Materials and Methods The gastric emptying and small intestinal transit were assessed by the phenol red content assay, modified from the method described by Izbeki et al (2001)
The small intestine was divided in the proximal (40%), medial (30%) and distal (30%) portions and each segment was homogenized in 100 mL of 0.1 N NaOH
Summary
According to Copaiba’s biologic classification, this plants belongs to Leguminosae family, subfamily Caesalpinoideae, genus Copaifera (Brito, 2000; Cascon, 2004; Maciel, 2002; Veiga Junior, 2005; Oliveira, 2006), and there is 72 species identified (Index Kewensis, 1996). Gastroprotection was observed with Copaifera langsdorfii (0.63 mL/kg) oil-resin, besides laxative effects (Brito, 2000).
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