Evaluation of Objective Signs and Subjective Symptoms of Dry Eye Disease in Patients with Inflammatory Bowel Disease.

Zsolt Barta,Eva Zold,Judit Zsuga,Judit Remenyik,Levente Czompa,Aniko Rentka,Attila Biro,Rudolf Gesztelyi,Peter Szodoray,Adam Kemeny-Beke

doi:10.1155/2019/8310583

Zsolt Barta, Eva Zold + Show 8 more

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https://doi.org/10.1155/2019/8310583

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Abstract

Aim To evaluate tear film parameters and relationship of objective clinical signs and subjective symptoms of dry eye disease (DED) in inflammatory bowel disease (IBD) subgroups. Methods 39 patients with Crohn's disease (CD), 26 patients with ulcerative colitis (UC), and 39 control persons with no ocular symptoms or surface disorders were included in this prospective, case-control, and cross-sectional study. The ocular surface disease index (OSDI) questionnaire was applied to evaluate dry eye symptoms, and objective tests of DED were performed on both eyes of each subject. Results The average of OSDI scores was 30.59 (±16.68) in CD patients, 24.67 (±23.48) in UC patients, and 11.19 (±5.8) in controls. Except for tear film breakup time (tBUT) and Schirmer-I values other objective parameters were better in UC patients, than in CD patients. CD patients rather than UC patients tend to develop DED. This was associated with immunosuppressant and TNF-α inhibitor use. Conclusions Clinicians must be aware of the spectrum of DED involvement in IBD and suggest using artificial tears in order to decrease severity of ocular complications.

Highlights

Inflammatory bowel disease (IBD) including Crohn’s disease (CD) and ulcerative colitis (UC) is a group of chronic inflammatory disorders principally affecting the intestines, but, being a systemic immune-mediated illness, it is not limited to the gastrointestinal (GI) tract [1,2,3]
39 patients with Crohn’s disease (CD), 26 patients with ulcerative colitis (UC), and 39 control persons with no ocular symptoms or surface disorders were included in this prospective, case-control, and cross-sectional study
Except for tear film breakup time and Schirmer-I values other objective parameters were better in UC patients, than in CD patients

Summary

Introduction

Inflammatory bowel disease (IBD) including Crohn’s disease (CD) and ulcerative colitis (UC) is a group of chronic inflammatory disorders principally affecting the intestines, but, being a systemic immune-mediated illness, it is not limited to the gastrointestinal (GI) tract [1,2,3]. It falls under the spectrum of global diseases as both its incidence and prevalence are increasing with an uneven occurrence in different regions all over the world [4]. No significant association of age and the occurrence of OEIMs in IBD was found by a prospective clinical study of a large population of IBD patients performed by Yilmaz et al [9]

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