Abstract
Cardamom seeds (Amomum compactum) or Kapulaga have been used as a flavoring spice in cooking. Besides, they are also useful in traditional medicine for oral health and gizzard, treating coughs and colds, maintaining kidney and urinary health, pain medication, preventing infections, as well as smoothing digestion. This study was aimed to evaluate the acetone extract of North Sumatera A. compactum as antibacterial and anticancer. The antibacterial activity test was carried out by the paper disc diffusion method. It was then followed by determination of minimum inhibitory concentration (MIC) and minimum kill concentration (MBC) against S. aureus ATCC 25923, S. mutans ATCV 35668 and E. faecalis ATCC 49619. The cytotoxic test was performed against MCF-7 cells. It has been found that acetone extract of A. compactum showed the best activity against S.aureus ATCC 25923 with a diameter of inhibition zone was of 8.3mm with MIC and MBC values of 625µg/mL. Acetone extract of A. compactum has anticancer breast activity with IC50 value was found to be 44.7828 µg/mL.
Highlights
Kapulaga is a native plant of Indonesia that grows wild in forests on the island of Java[1]
It has been found that acetone extract of A. compactum showed the best activity against S.aureus ATCC 25923 with a diameter of inhibition zone was of 8.3mm with minimum inhibitory concentration (MIC) and Minimum Bactericidal Concentration (MBC) values of 625μg/mL
While in Malaysia A. compactum seeds are used as cough and fever medicines[3], in Indonesia cardamom is used as an aromatic ingredient, treating cough, bad breath, and itchy throat[4]
Summary
Kapulaga is a native plant of Indonesia that grows wild in forests on the island of Java[1]. The type of cardamom most commonly found in Indonesia is cardamom java (A. compactum). It is widely used for cooking spices, health drinks, traditional medicine and aromatherapy[2]. That many have been cultivated in various regions in Indonesia. In traditional Chinese medicine, A. compactum seeds have been used to treat various diseases such as digestive disorders, stomach disorders, and antipyreticemmenagogues. While in Malaysia A. compactum seeds are used as cough and fever medicines[3], in Indonesia cardamom is used as an aromatic ingredient, treating cough, bad breath, and itchy throat[4]
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