Abstract
Abstract A reversed phase HPLC assay was used to measure partition coefficients for salicylic acid, salicylamide and salicyluric acid in two-phase systems employing neat or aqueous ethylene glycol, formamide, or methanol and the organic solvents: ethylene dichloride, ethyl acetate, diethyl ether and methyl isobutyl ketone. These solvent systems permit preparative separation by countercurrent chromatography of compounds with limited aqueous solubility. Salicylic acid, salicylamide and salicyluric acid are readily separated in the system employing ethylene glycol as the stationary phase and diethyl ether as the mobile phase.
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