EVALUATION OF NEUTROPHIL LYMPHOCYTE RATIO, PLATELET LYMPHOCYTE RATIO AND MEAN PLATELET VOLUME IN MAJOR DEPRESSIVE DISORDER

Abstract

Objective
 The relationship between chronic inflammation and
 psychiatric disorders has been evaluated in previous
 studies. Neutrophil-lymphocyte ratio (NLR), platelet-
 lymphocyte ratio (PLR), and mean platelet volume
 (MPV) appear to be new markers for the evaluation of
 systemic inflammatory response. In this study, it was
 aimed to evaluate the levels of NLR, PLR and MPV
 biomarkers in patients with major depressive disorder
 (MDD) by comparing them with healthy controls, and
 also investigate the relationship between biomarkers
 and MDD.
 Material and Method
 This cross-sectional study was carried out from
 July 15, 2020 to May 15, 2021. The study was
 conducted with 92 patients with diagnosed MDD and
 72 healthy controls who agreed to participate. The
 sociodemographic data form and SCID-5/CV form
 were filled out for each participant through face-to-face
 interviews with all participants. Additionally, Hamilton
 Depression Scale was applied to the patient group to
 determine the severity of MDB.
 Results
 Patients with MDD and healthy controls were
 compared in terms of the mean scores of NLR, PLR
 and MPV, and no statistically significant difference was
 found between the groups (p>0.05). Additionally, in
 the patient group, there was no statistically significant
 difference between the levels of depression severity
 (mild, moderate, severe) in terms of the mean scores
 of NLR, PLR, and MPV (p>0.05).
 Conclusion
 This is the first study to evaluate NLR, PLR and
 MPV biomarkers simultaneously in MDD patients by
 comparing them with healthy controls. In this study,
 it was found that there was no significant relationship
 between NLR, PLR and MPV levels and MDD.
 Additionally, it was determined that there was no
 relationship between the severity of depression and the
 aforementioned markers. Further studies investigating
 these and another biomarkers with prospective
 and larger studies will provide more insight into the
 inflammatory process in MDD.