Abstract
BackgroundDehydration caused by acute rotavirus gastroenteritis is a frequent finding in pediatric patients. The most important treatment modality in these patients is recognising and treating dehydration, electrolyte imbalance and acute kidney injury. Neutrophil gelatinase-asssociated lipocalin (NGAL) is used widely as a biomarker for the diagnosis of acute or chronic renal injury in numerous clinical studies. It is recognized as an early marker of acute renal failure before the elevation of routine biochemical tests such as creatinine. The aim of this study is to investigate the plasma and urine NGAL concentrations in mildly or moderately dehydrated patients with acute rotavirus gastroenteritis.Material and methodsA total of 30 patients (13 girls, mean age 62.5 ± 46.2 months) with diarrhea and mild/moderate dehydration and 35 healthy controls (17 girls, mean age 81.1 ± 41.8 months) were enrolled in the study. Plasma and urine NGAL levels of the two groups were compared.ResultsThe mean age, gender and serum creatinine levels of the patients and healthy controls were similar. The mean plasma and urine NGAL levels of the patients were significantly higher than controls (plasma: 118.6 ± 81.2 vs. 66.5 ± 11.3, p = 0.001 and urine: 17.7 ± 17.5 vs. 10.6 ± 7.9, p = 0.035, respectively).ConclusionMildly or moderately dehydrated children have higher plasma and urine NGAL levels compared to control subjects. Plasma and/or urine NGAL levels can be used for the early prediction of renal impairment in children with mild or moderate dehydration.
Highlights
Dehydration caused by acute rotavirus gastroenteritis is a frequent finding in pediatric patients
Plasma and/or urine Neutrophil gelatinase-asssociated lipocalin (NGAL) levels can be used for the early prediction of renal impairment in children with mild or moderate dehydration
The mean plasma and urine NGAL levels of the patients were significantly higher in patient group than controls (p = 0.001 and p = 0.035, respectively) (Table 1)
Summary
Dehydration caused by acute rotavirus gastroenteritis is a frequent finding in pediatric patients. Neutrophil gelatinase-asssociated lipocalin (NGAL) is used widely as a biomarker for the diagnosis of acute or chronic renal injury in numerous clinical studies. It is recognized as an early marker of acute renal failure before the elevation of routine biochemical tests such as creatinine. The most important treatment modality in these patients is recognizing and treating dehydration, electrolyte imbalance and acute kidney injury. Human “Neutrophil gelatinase-asssociated lipocalin” (NGAL, lipocalin 2) was originally identified as a 25-kDa protein covalently bound to gelatinase from neutrophils [3,4]. It was shown that NGAL was a potent early biomarker of renal injury in numerous clinical studies [6,7,8,9,10,11,12]
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