Abstract
Dichrostachys cinerea (DC) root juice is widely used by tribals of Chittoor District against paralysis. The ethanolic extract was given at a dose of 100, 200 and 400 mg/kg/p.o. Spontaneous motor activity, analgesia, grip strength, alertness and immobility in tail suspension test (TST) and forced swimming test (FST) were assessed. The extract at given doses significantly dose dependently decreased exploratory activity, spontaneous motor activity, increased immobility time in both FST and TST, decreased climbing and swimming behaviour in FST and did not alter other parameters. Preliminary phytochemical analysis of ethonolic extract showed the presence of saponins, steroids, glycosides, carbohydrates and tannins.
 Results of the present study indicated that the alcoholic extract may have active constituents with CNS depressant activity and at the given doses they are devoid of memory impairment and neurotoxicity
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