Abstract
BackgroundDiabetic is one of the fundamental persuasive of diabetic nephropathy and significantly sparks off kidney diseases and end stage renal failure globally.MethodThe current research was carried out to evaluate hypoglycemic potential and nephroprotective effect of ethanolic extract of Mikania scandens leaves by using alloxan-induced diabetic nephropathy (DN) mice. The mice were intraperitoneally treated with (200 mg/kg) Mikania scandens leaves extract and standard (120 mg/kg) metformin HCL solution up to 22 days. During this treatment period, we collected blood for evaluation of different types of parameters such as blood glucose level body weight at 0, 15, 22th days, serum creatinine, uric acid, total protein were estimated at the end of the experiment (day 22).ResultMikania scandens leaves extract significantly (p < 0.05) lessen blood glucose level, serum creatinine, total protein and uric acid. Apart this, cytotoxicity studies were assessed by Brine Shrimp Lethality Bioassay. By this method, we measure the dose of LC50. The plant has high LC50 dose thus cytotoxicity has ensued at massive amount and safe to administer.ConclusionLowering of serum creatinine, uric acid and total protein recommend that the ethanolic extract of Mikania scandens possess potent nephroprotective activity and assure the traditional avail of this plant in the management of diabetes nephropathy.
Highlights
Diabetic is one of the fundamental persuasive of diabetic nephropathy and significantly sparks off kidney diseases and end stage renal failure globally
Lowering of serum creatinine, uric acid and total protein recommend that the ethanolic extract of Mikania scandens possess potent nephroprotective activity and assure the traditional avail of this plant in the management of diabetes nephropathy
Effects of EMSL on body weight in alloxan induced diabetic nephropathy mice The effect of intra-peritoneal administration of alcoholic leaves extract of Mikania scandens in diabetic nephropathy mice is presented in Table 1 and Fig. 1
Summary
Diabetic is one of the fundamental persuasive of diabetic nephropathy and significantly sparks off kidney diseases and end stage renal failure globally. Diabetic kidney disease is a leading phenomenon of chronic and end-stage-renal disease worldwide and the prime predictor of mortality in patient with diabetes [1]. 30% of all diabetic patients metamorphose into diabetic nephropathy (2020) 6:20 Groups. Mikania scandens (L) is popularly used as a herbal remedy for various ailments of Bangladesh. In Bangladesh, M. scandens is known as “Jarmany lota” [7]. In-vitro experiments asserted that the flowers exposed anti-inflammatory properties [12]. It has analgesic, in vitro antioxidant and antidiabetic activities of leaf material [13]
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