Evaluation of myocardial viability in myocardial infarction patients by magnetic resonance perfusion and delayed enhancement imaging.

Abstract

Cardiovascular magnetic resonance imaging (CMR) has been established as amodality to detect myocardial viability. The aim of this study was to evaluate myocardial viability by observing transmural extent of infraction and microvascular perfusion level. We performed CMR in 30myocardial infarction (MI) patients within 7-10days. At the 6‑month follow-up, CMR was used to evaluate the impact of abnormal reperfusion and observe the transmural extent of infraction on recovery of function. The left ventricle was divided into 16segments using the American Heart Association classification. Infarcts were detected in 202 of the 480 segments (42%) by delayed enhancement magnetic resonance imaging (DE-MRI). According to first-pass myocardial perfusion, abnormal perfusion was detected in 278 of 480 segments (60%), reduced perfusion was identified in 173 of 278 (62%), and perfusion defects in 105 of 278 segments (38%). The results showed that the segments with abnormal perfusion were larger than in DE-MRI (P < 0.05), indicating that the area of abnormal perfusion segments extend significantly beyond the region of infarction. Microvascular perfusion with an infarcted region was lower compared to non-infarcted segments (P < 0.05). The extent of myocardial hyperenhancement correlated inversely with microvascular perfusion (P < 0.05). Segments with severe microvascular perfusion and >75% transmural infarction on the 7‑ to 10-day scan had markedly increased at the 6‑month follow-up (P < 0.01), indicating alack of recovery of cardiac function. DE-MRI combined with microvascular perfusion may be effective to detect viable myocardium in patients with MI and may provide ameans of predicting whether revascularization will be effective.