Abstract
Cinnamomum plants (Lauraceae) are a woody species native to South and Southeast Asia forests, and are widely used as food flavors and traditional medicines. This study aims to evaluate the chemical constituents of Cinnamomum osmophloeum ct. linalool leaf oil, and its antidepressant and motor coordination activities and the other behavioral evaluations in a rodent animal model. The major component of leaf oil is linalool, confirmed by GC-MS analysis. Leaf oil would not induce the extra body weight gain compared to the control mice at the examined doses after 6 weeks of oral administration. The present results provide the first evidence for motor coordination and antidepressant effects present in leaf oil. According to hypnotic, locomotor behavioral, and motor coordination evaluations, leaf oil would not cause side effects, including weight gain, drowsiness and a diminishment in the motor functions, at the examined doses. In summary, these results revealed C. osmophloeum ct. linalool leaf essential oil is of high potential as a therapeutic supplement for minor/medium depressive syndromes.
Highlights
IntroductionPublisher’s Note: MDPI stays neutral with regard to jurisdictional claims in published maps and institutional affiliations
Cinnamomum osmophloeum Kanehira is one of the traditional medicinal plants; its bark is used as a folk medicine for treating colds and improving gastrointestinal function
The study demonstrated the behavioral effects of C. osmophloeum ct. linalool leaf oil after oral administration in mice, the motor coordination and antidepressant activities of leaf oil were firstly reported by a rodent model system, to the best of our knowledge
Summary
Publisher’s Note: MDPI stays neutral with regard to jurisdictional claims in published maps and institutional affiliations. Cinnamon plants (Cinnamomum species, Lauraceae) are one of the important natural product resources from forests and are used as the well-known spice and ethnopharmacological remedy. Cinnamomum osmophloeum Kanehira is one of the traditional medicinal plants; its bark is used as a folk medicine for treating colds and improving gastrointestinal function. Essential oils are distilled from its leaves, bark and seeds for various purposes
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