Evaluation of Morphological (Macroscopic and Microscopic) Parameters of Placentas in Pregnancies Complicated by Preeclampsia, Diabetes and Preeclampsia and Diabetes

Abstract

This study was done to compare the morphometric parameters of placentas in well controlled patients withpreeclampsia, diabetes, and preeclampsia-diabetes with that of normal uncomplicated placentas.Patients &Methods: A total of Twenty four placentas were freshly collected. Six placentas for controlgroup and eighteen placentas for complicated group (preeclamptic- diabetic and preeclamptic--diabeticsubgroups). The placentas were grossly examined (shape, number of cotyledons, weight, and thickness).After suitable fixation, tissue processing and sectioning, the sections were stained by hematoxylin and eosinto study the general morphology and morphometry of the following parameters: number of terminal villi,number of syncytial knots, number of apoptotic cells and number of fetal capillaries.Result: The weight of the baby in D- subgroup was significantly increased when compared with controlgroup and with P and P-D subgroups . Microscopical morphometry regarding number of terminal villi,apoptotic cells, syncytial knots and fetal capillaries were increased in complicated subgroups. The thicknessof basement membrane was 0.8µm in control group and it was increased in all complicated subgroups. Thehighest value was reported by D- subgroup (2 µm).